Ultrasensitive detection of bacteria using core-shell nanoparticles and a NMR-filter system
Original entry: Warren Lloyd Ung, APPHY 225, Fall 2009
"Ultrasensitive detection of bacteria using core-shell nanoparticles and a NMR-filter system"
Hakho Lee, Tae-Jong Yoon, and Ralph Weissleder.
Angewandte Chemie Internation Edition (2009).
Soft Matter Keywords
magnetic nanoparticles, biosensors, NMR, microfluidics
Lee et al have constructed a device, which can detect bacteria in biological samples, by attaching magnetic nanoparticles (MNP) to the bacteria of interest, and observing the resultant nuclear magnetic resonance (NMR) signal. In this particular study, they demonstrate the capacity for detecting small quantities of Mycobacterium tuberculosis in the context of a relevant biological context, sputum. Such a device could have an impact on point of care diagnosis of infectious diseases, such as tuberculosis, which is still a major cause of death worldwide. In addition, the techniques introduced here are general enough that they could be applied to the detection of many different kinds of bacteria in a wide range of samples.
The detection of the bacterial pathogens behind various kinds of diseases and symptoms is a powerful tool for physicians and other medical personnel.