Supramolecular Assembly of Biological Molecules Purified from Bovine Nerve Cells: from Microtubule Bundles and Necklaces to Neurofilament Networks

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Zach Wissner-Gross (March 16, 2009)


Supramolecular assembly of biological molecules purified from bovine nerve cells: from microtubule bundles and necklaces to neurofilament networks

Daniel J. Needleman, Janya B. Jones, Uri Raviv, Miguel A. Ojeda-Lopez, H. P. Miller, Y. Li, L. Wilson, and C. R. Safinya

Journal of Physics: Condensed Matter, 2005, 17, S3225-S3230

Soft matter keywords

Self-assembly, packing structure


Needleman et al. examine the behavior of neurofilaments (NFs) in vitro in solutions containing different polyelectrolytes (i.e., in different salt solutions). In short, they found that the NFs formed hexagonal bundles in solutions with containing cations with a greater charge and larger size, while the NFs formed what the authors term "living necklace bundles" in solutions containing bivalent cations (Figure 1).