Shape Memory Polymer Stent With Expandable Foam: A New Concept for Endovascular Embolization of Fusiform Aneurysms
Original entry: William Bonificio, AP 225, Fall 2009
Shape Memory Polymer Stent With Expandable Foam: A New Concept for Endovascular Embolization of Fusiform Aneurysms. IEEE Transactions in Biomedical Engineering, vol. 54, no. 6, 2007, pg. 1157
Soft matter keywords
Magnetotactic Bacteria, paramagnetism, iron oxide, colloids, debye length.
The purpose of this study was to propose a new device for the therapy of non-necked aneurysms. The researchers proposed a shape memory stent be combined with a shape memory foam in order to produce an embolism that fills the aneurysm with the foam, and a stent which provides blood flow, all in a single device. Current methods are much more invasive, and also take a longer time involving multiple procedures. A further explanation of these aneurysms and the device that was formed is below.
Soft matter discussion
Cerebral aneurysms occur when blood collects in these pockets in the circulatory system, that then grow due to pressure, becoming very weak, and then rupturing, often having fatal results. Many aneurysms are treated by embolizing, or filling the pocket so that the walls of the aneurysm do not feel the pressure of the blood. This can be done with coils, or balloons, or a combination of these things along with stents. These procedures can become very complicated and invasive depending on different factors, such as the size or existence of the neck of the aneurysm, because this often determines what type of embolization can be done. With wide neck aneurysms many current embolizing agents can escape the aneurysm and cause harm down stream.
The researchers on this project proposed a new device which combined a shape memory stent, used to ensure blood flow, and a shape memory foam, used for embolization, for the therapy of the fusiform gyrus nonnecked aneurysm. Shape memory polymers (SMPs) utilize the shape change and deformation that occur during phase changes to take advantage of the glass transition temperature and produce a shape memory effect. First the researchers created a 'memorized' shape of the SMP. They then raised the SMP above its Tg and worked the stent and foam into the desired compacted shape and and cooled it below its Tg and 'froze' it in place. When the SMP is raised above its Tg, the modulus will change and the SMP will retake the original form. This obviously has value in this problem because the stent and foam can be inserted laproscopically through blood vessels with minimal invasiveness.