Relationship between cellular response and behavioral variability in bacterial chemotaxis
Original Entry: Tom Dimiduk APPHY, Fall 2010
Relationship between cellular response and behavioral variability in bacterial chemotaxis Thierry Emonet† and Philippe Cluzel Proceedings of the National Academy of Sciences
Soft Matter Keywords
Random Walk, Fluctuation Dissipation, Population Behavior
This article discusses how amplification of noise in an enzyme system is used to drive the bacteria's stochastic response to nutrient gradients. The authors find that hypersensitivity to these fluctuations actually provides beneficial behaviors both for allowing single bacteria to progress rapidly up gradients and for allowing populations to explore a large area. Finally, the dynamics of bacteria in response to stimulus can be inferred from their spontaneous fluctuations in the absence of stimuli.
Soft Matter Discussion
This paper presents only computational results, so take that into consideration when considering these results.
The first portion of their results is a lengthy discussion of enzyme dynamics which is of little interest from a soft matter perspective. The important result is that increasing expression of the CheY-P kinase reduces fluctuations in control loops (Figure 3), reducing the power spectrum of the "output" (related to lengths of bacterial "runs").
They observe that increasing CheY-P, and thus decreasing fluctuations, reduces the rate at which the bacteria progress (Figure 4), by shortening the length of runs while going up a gradient.