Difference between revisions of "Protein folding on rugged energy landscapes: Conformational diffusion on fractal networks"

From Soft-Matter
Jump to: navigation, search
Line 8: Line 8:
  
 
The article can be found [http://jamming.research.yale.edu/files/papers/PhysRevE.81.051907.pdf here].
 
The article can be found [http://jamming.research.yale.edu/files/papers/PhysRevE.81.051907.pdf here].
 +
 +
 +
==Overview and Comments==
 +
This paper tackles the difficult problem of how a protein navigates a wide selection of metastable states to fold into its lowest-energy native state.  This is a question of great importance to biology, where the correct conformation of a protein is essential to its function.  The authors find that there is no fixed pathway a model protein follows during folding, but rather there is an ensemble of paths leading to the native state.  Furthermore, for a "rugged" energy landscape (that is, a landscape in which the activation barriers between local minima are comparable to the depth of the desired minimum), the local kinetics of transitions between metastable states are less important than the fractal nature of the network of states visited and transitions between them.

Revision as of 17:45, 20 October 2010

Gregg Lois, Jerzy Blawzdziewicz, and Corey S. O'Hern

Physical Review E 81 (2010) 051907


wiki entry by Emily Russell, Fall 2010


The article can be found here.


Overview and Comments

This paper tackles the difficult problem of how a protein navigates a wide selection of metastable states to fold into its lowest-energy native state. This is a question of great importance to biology, where the correct conformation of a protein is essential to its function. The authors find that there is no fixed pathway a model protein follows during folding, but rather there is an ensemble of paths leading to the native state. Furthermore, for a "rugged" energy landscape (that is, a landscape in which the activation barriers between local minima are comparable to the depth of the desired minimum), the local kinetics of transitions between metastable states are less important than the fractal nature of the network of states visited and transitions between them.