Particle/Fluid Interface Replication as a Means of Producing Topographically Patterned Polydimethylsiloxane Surfaces for Deposition of Lipid Bilayers

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Qichao Hu


Microstructured surfaces are common, but their fabrication techniques typically involve some form of photolithography, and the patterning is limited to two-dimensions. In order to achieve patterning in the third dimension, etching is used following the photolithography. Although these techniques can create three dimensional microstructured patterns, they are complex and involve cleanroom or microfabrication facilities. This paper introduces a new method using a particle-studded fluid-fluid interface to produce topographically patterned PDMS surfaces. The advantage of this method is that it does not involve harsh chemicals or cheanroom facilities.