Microwave dielectric heating of drops in microfluidic devices
"Microwave dielectric heating of drops in microfluidic devices"
David Issadore, Katherine J. Humphry, Keith A. Brown, Lori Sandberg, David A. Weitz, and Robert M. Westervelt
Lab on a Chip Online advance article (2009)
Soft Matter Keywords
microfluidic, emulsion, dielectric heating
Practical Application of Research
The research begins to open up the possibility of localized temperature control in microfluidic systems. Most systems to date have spatial control down to a few centimeters, but this work pushes temperature control to the 100s of microns scale. The heating and cooling of the water droplets occurs on timescales much shorter than previously accessible. With temperature changes of nearly 30 degrees above ambient achievable, the microwave heating paradigm can be applied to biologically relevant systems, including PCR reactions for DNA analysis, as well as protein denaturing studies and enzyme optimization. Combining this rapid heating with the high-throughput capabilities of microfluidic emulsions has the potential to allow researchers to analyze large sample populations of temperature sensitive reactions.
Dielectric Heating of Water Drops On-Chip
written by Donald Aubrecht