Microrheology of Microtubule Solutions and Actin-Microtubule Composite Networks

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Microrheology of Microtubule Solutions and Actin-Microtubule Composite Networks, Vincent Pelletier, Naama Gal, Paul Fournier and Maria Kilfoil, PRL vol.102 188303 (2009) [1]


Microrheology, Cytoskeleton, Viscoelasticity

Original Abstract from Paper

"We perform local or microrheological measurements on microtubule solutions, as well as composite networks. The viscoelastic properties of microtubules as reported from two-point microrheology agree with the macroscopic measurement at high frequencies, but appear to show a discrepancy at low frequencies, at time scales on the order of a second. A composite of filamentous actin (F-actin) and microtubules has viscoelastic behavior between that of F-actin and pure microtubules. We further show that the Poisson ratio of the composite, measured by the length-scale dependent two-point microrheology, is robustly smaller than that of the F-actin network at time scale <math>\tau</math> > 1 s, suggesting that a local compressibility is conferred by the addition of microtubules to the F-actin network."

Soft Matter

Figure 1