Micromanipulation of biological cells using a microelectromagnet matrix
Original entry by Sagar Bhandari, APPHY 225 Fall 2010
H. Lee, A.M. Purdon, R.M. Westervelt, "Manipulation of Biological Cells using a Microelectromagnet Matrix", Applied Physics Letters 85, 1063 (2004).
cells, microelectromagnet, manipulation
In this paper, the authors demonstrate the noninvasive manipulation of biological cells by microelectromagnetic matrix created using lithography techniques. An array of straight wires aligned perpendicular to each other are created on a Si/SiO2 substrate.
Yeast cells were attached to magnetic beads by having the surface of the magnetic bead functionalized with Concanavalin–A, a lectin that specifically binds to sugar molecules15 (a-D-mannose) on the yeast cell’s surface with a binding force of approximately 100 pN.