Membrane Interactions of Novicidin, a Novel Antimicrobial Peptide:

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Entry by Angelo Mao, AP 225, Fall 2010

Title: Membrane Interactions of Novicidin, a Novel Antimicrobial Peptide: Phosphatidylglycerol Promotes Bilayer Insertion

Authors: Dorosz J, et al

Journal: J. Phys. Chem. B

Volume: Vol 114(34)

Pages: 11053-11060


Summary

Novicidin is a novel antimicrobial peptide that is an improvement on certain preexisting antimicrobial peptides (such as melittin) in that it more effectively targets bacteria and causes less hemolysis. Through various experiments, the researchers propose that an explanation for this difference is the relative proportion of hydrophobic to hydrophilic elements in novicidin composition, as well as the locations of these elements, which lowers the free energy of novicidin interaction and embedding in negative (bacterial) membranes in comparison to zwitterionic (human) membranes.

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