Long-distance propagation of forces in a cell

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Entry by Angelo Mao, AP 225, Fall 2010

Title: Long-distance propagation of forces in a cell

Authors: Ning Wang, Zhigang Suo

Journal: Biochemical and Biophysical Research Communications

Volume: 328 (2005)

Pages: 1133–1138


The researchers propose two theoretical models for the propagation of "locally applied forces" throughout the body of a cell. Contrary to preexisting models, these models balance the effects of the actin bundles running throughout the inside of the cells against the cytoskeleton network. These models predict that the effects of force propagation via stiff actin bundles would far supersede the effects of force dampening via the cell's cytoskeleton. The results of theory are confirmed by experimentally applying a "local" force on the cell surface and observing where force deformations occur. Both theoretical and experimental results contribute insight to force propagation in the cell, which, in turn, has implications for cell signaling, behavior, and integrity.