Difference between revisions of "Long-distance propagation of forces in a cell"

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'''Theoretical models''' The researchers proposed two theoretical models: one for longitudinal stresses, called the ''stiff fiber model'', and one for transverse forces, called the ''prestressed string model'', as applied to the actin bundle.  
 
'''Theoretical models''' The researchers proposed two theoretical models: one for longitudinal stresses, called the ''stiff fiber model'', and one for transverse forces, called the ''prestressed string model'', as applied to the actin bundle.  
  
In the ''prestressed string model'', the prestress keeping the actin bundles taut exerts a force of <math>h_{b}^{2} \sigma_{b} \partial^{2} v/ \partial x^{2} dx</math>
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In the ''prestressed string model'', the prestress keeping the actin bundles taut exerts a force of <math> h_{b}^{2} \sigma_{b} \partial^{2} v/ \partial x^{2} dx</math> and is countered by the restoring force of the CSK, which is <math> (G_{m}v/h_{m})h_{b}dx </math>. Equating the two yields a characteristic length <math>L_{1} = \sqrt{ \alpha_{b} h_{b} h_{m}/G_{m}}</math>.

Revision as of 18:25, 13 September 2010

Entry by Angelo Mao, AP 225, Fall 2010

Title: Long-distance propagation of forces in a cell

Authors: Ning Wang, Zhigang Suo

Journal: Biochemical and Biophysical Research Communications

Volume: 328 (2005)

Pages: 1133–1138

Summary

The researchers propose two theoretical models for the propagation of "locally applied forces" throughout the body of a cell. Contrary to preexisting models, these models balance the effects of the actin bundles running throughout the inside of the cells against the cytoskeleton network. These models predict that the effects of force propagation via stiff actin bundles would far supersede the effects of force dampening via the cell's cytoskeleton. The results of theory are confirmed by experimentally applying a "local" force on the cell surface and observing where force deformations occur. Both theoretical and experimental results contribute insight to force propagation in the cell, which, in turn, has implications for cell signaling, behavior, and integrity.

Soft Matter Keywords: cell, in vitro, actin, force, modulus

Theoretical Summary

Background AM-1-1 model.png
The researchers modeled the cell's interior as being governed by primarily two forces: actin fibers that could act as "force guides" and transmit force from the surface, where it occurred, to distances as far away as the cell diameter; and the internal cytoskeleton (CSK) network, which worked to homogenize the cell. If the force of the CSK network predominated, then the cell should act homogeneously, and the force should dissipate over a distance on the order of the size of the local application.

Theoretical models The researchers proposed two theoretical models: one for longitudinal stresses, called the stiff fiber model, and one for transverse forces, called the prestressed string model, as applied to the actin bundle.

In the prestressed string model, the prestress keeping the actin bundles taut exerts a force of <math> h_{b}^{2} \sigma_{b} \partial^{2} v/ \partial x^{2} dx</math> and is countered by the restoring force of the CSK, which is <math> (G_{m}v/h_{m})h_{b}dx </math>. Equating the two yields a characteristic length <math>L_{1} = \sqrt{ \alpha_{b} h_{b} h_{m}/G_{m}}</math>.