Liposome

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Prepared by Max Darnell - AP225 Fall 2011

Definition

Lipids can be thought of as micelles with both inner and outer hydrophobic portions. These constructs are comprised of phospholipids which are ampipathic, meaning that they contain both hydrophilic and hydophobic regions. In aqueous solutions, these phospholipids self-assemble to shield their hydrophobic regions from the solvent. Lipososmes form when the "shell" consists of a double layer of lipids such that the interior is an aqueous solution as well. They were discovered in 1961.

Liposome


Applications/Connections to Soft Matter

References

Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., & And Walter, P. (2008). Molecular Biology of the Cell. (Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, & P. Walter, Eds.) Garland Press.

Keyword in references:

All-aqueous core-shell droplets produced in a microfluidic device

C2AB: A Molecular Glue for Lipid Vesicles with a Negatively Charged Surface