Difference between revisions of "Levinthal's Paradox"

From Soft-Matter
Jump to: navigation, search
Line 3: Line 3:
 
Entry needed.
 
Entry needed.
  
Levinthal's paradox is an apparent contradiction between the number of possible conformations for a protein chain and the fact that proteins can fold to their native conformation quickly (less than a second). In the proceedings where Levinthal first mentioned the paradox that bears his name, he estimates that for a protein there are 10<sup>300</sup> possible conformations. Using the amount of time it actually takes for a protein to fold to its native conformation and assuming the minimal amount of time to sample different conformations, the protein would only be able to sample ~10<sup>8</sup> different conformations.
+
It is well known that proteins in solution can reliably fold from a random coil to a unique native conformation on a biologically relavent timescale. Levinthal's paradox is an apparent contradiction between the number of possible conformations for a protein chain and the fact that proteins can fold to their native conformation quickly (less than a second). In the proceedings where Levinthal first mentioned the paradox that bears his name, he estimates that for a protein there are 10<sup>300</sup> possible conformations. Using the amount of time it actually takes for a protein to fold to its native conformation and assuming the minimal amount of time to sample different conformations, the protein would only be able to sample ~10<sup>8</sup> different conformations if the protein sampled the conformation space randomly.
  
 
==References==
 
==References==

Revision as of 04:43, 4 December 2011

Peter Foster, In progress Fall 2011

Entry needed.

It is well known that proteins in solution can reliably fold from a random coil to a unique native conformation on a biologically relavent timescale. Levinthal's paradox is an apparent contradiction between the number of possible conformations for a protein chain and the fact that proteins can fold to their native conformation quickly (less than a second). In the proceedings where Levinthal first mentioned the paradox that bears his name, he estimates that for a protein there are 10300 possible conformations. Using the amount of time it actually takes for a protein to fold to its native conformation and assuming the minimal amount of time to sample different conformations, the protein would only be able to sample ~108 different conformations if the protein sampled the conformation space randomly.

References

[1] Levinthal's Paradox


Keyword in references:

G. Lois, J. Blawzdziewicz, and C. S. O'Hern, "Protein folding on rugged energy landscapes: Conformational diffusion on fractal networks", Phys. Rev. E 81 (2010) 051907

Reliable Protein Folding on Complex Energy Landscapes: The Free Energy Reaction Path