Interdependence of behavioural variability and response to small stimuli in bacteria

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Original Entry: Peter Foster, AP 225, Fall 2011

General Information

Authors: Heungwon Park, William Pontius, Calin C. Guet, John F. Marko, Thierry Emonet & Philippe Cluzel

Publication: Park et al. Interdependence of behavioural variability and response to small stimuli in bacteria. Nature (2010) vol. 468 (7325) pp. 819-U114

Summary

The goal of this paper [1] was to test whether or not a connection could be made between between natural variability and stimulus response in cells. This was examined using the E. coli chemotaxis network. The chemotaxis network regulates cellular movement by controlling whether flagella rotate in the clockwise (CW) or counterclockwise (CCW) direction. When the flagella rotate in the CCW direction, they form a bundle and propel the cell forward and when they rotate in the CW direction the bundle unravels and randomly orients the cell. The signaling network serves to regulate the probability that the motors rotate in the CW vs. the CCW direction.


Figure 1, taken from [1].

Discussion

- FRT extension of FDT to system far from thermal equilibrium

References

[1] Park et al. Interdependence of behavioural variability and response to small stimuli in bacteria. Nature (2010) vol. 468 (7325) pp. 819-U114