Fluorination

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Definition

Fluorination is the chemical process of adding the element fluorine into a molecule. Fluorine has atomic number 9 and is in group 17, the halogens. Fluorination is a kind of halogenation. This periodic table is from wikimedia commons and shows Fluorine's position at the top of the Halogens (group 17).

Applications

  • Fluorinating a surface or applying a fluorinated coating lowers the surface energy and makes the surface more hydrophobic. Desbief et. al. [3] coat an aluminum surface with fluorinated block copolymers to make the aluminum more hydrophobic.
  • Lots of common pharmaceuticals are fluorinated. Fluorinating a pharmaceutical makes it more lipophilic, enhancing absorption of the drug. Some fluorinated pharmaceuticals include Prozac, Paxil, Celebrex, and Lipitor. The pros and cons of fluorinated drugs and their effect on the environment are a topic of debate.

References

[1] Halogenation. (accessed Oct. 19, 2009). http://en.wikipedia.org/wiki/Halogenation

[2] Fluorination. "The American Heritage Dictionary of the English Langage," Houghton Mifflin Company. 4th Ed. (2000). http://www.thefreedictionary.com/fluorination

[3] Desbief, S., Grignard, B., Detrembleur, C., Rioboo, R., Vaillant, A., Seveno, D., Voue, M., De Coninck, J., Jonas, A.M., Jerome, C., Damman, P., and Lazzaroni, R. "Superhydrophobic Aluminum Surfaces by Deposition of Micelles of Fluorinated Block Copolymers,"Langmuir (2009). doi: 10.1021/la902565y.

[4] Ismail, F. "Important Fluorinated Drugs in Experimental and Clinical Use," Journal of Fluorine Chemistry 118, 27-33 (2002).

[5] A Second Look. "Index of Fluorinated Pharmaceuticals," Fluoride Toxidity Reserach Collaborative (accessed Oct. 19, 2009). http://www.slweb.org/ftrcfluorinatedpharm.html