Difference between revisions of "Fluorination"
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== Applications == | == Applications == | ||
| − | * Fluorinating | + | * Fluorinating or applying a fluorinated coating to a surface lowers the surface energy and makes the surface more hydrophobic. Desbief ''et. al.'' [[Superhydrophobic Aluminum Surfaces by Deposition of Micelles of Fluorinated Block Copolymers|[3] ]] coat an aluminum surface with fluorinated block copolymers to make the aluminum more hydrophobic. |
| − | *Many companies make fluorinated plastic containers | + | *Many companies make fluorinated plastic containers that are less permeable than plain HDPE containers. |
**http://www.thecarycompany.com/containers/plastic_bottles/fluorination.html | **http://www.thecarycompany.com/containers/plastic_bottles/fluorination.html | ||
**http://www.novapak.com/news/Articles/Fluorination.asp | **http://www.novapak.com/news/Articles/Fluorination.asp | ||
| − | *Lots of common pharmaceuticals are fluorinated. Fluorinating a pharmaceutical makes it more lipophilic, enhancing absorption of the drug. | + | *Lots of common pharmaceuticals are fluorinated. Fluorinating a pharmaceutical makes it more lipophilic, enhancing absorption of the drug [4]. Common fluorinated pharmaceuticals include Prozac, Paxil, Celebrex, and Lipitor [5]. The pros and cons of fluorinated drugs and their effects on the environment are a topic of debate. |
**http://www.slweb.org/ftrcfluorinatedpharm.html | **http://www.slweb.org/ftrcfluorinatedpharm.html | ||
== References == | == References == | ||
| − | [1] Halogenation | + | [1] "Halogenation," ''Wikipedia'' (accessed Oct. 19, 2009). http://en.wikipedia.org/wiki/Halogenation |
| − | [2] Fluorination | + | [2] "Fluorination," ''The American Heritage Dictionary of the English Langage,'' Houghton Mifflin Company. 4th Ed. (2000). http://www.thefreedictionary.com/fluorination |
| − | [3] Desbief, S., Grignard, B., Detrembleur, C., Rioboo, R., Vaillant, A., Seveno, D., Voue, M., De Coninck, J., Jonas, A.M., Jerome, C., Damman, P., and Lazzaroni, R. "Superhydrophobic Aluminum Surfaces by Deposition of Micelles of Fluorinated Block Copolymers,"''Langmuir'' (2009). doi: 10.1021/la902565y. | + | [3] Desbief, S., Grignard, B., Detrembleur, C., Rioboo, R., Vaillant, A., Seveno, D., Voue, M., De Coninck, J., Jonas, A.M., Jerome, C., Damman, P., and Lazzaroni, R. "Superhydrophobic Aluminum Surfaces by Deposition of Micelles of Fluorinated Block Copolymers," ''Langmuir'' (2009). doi: 10.1021/la902565y. |
[4] Ismail, F. "Important Fluorinated Drugs in Experimental and Clinical Use," ''Journal of Fluorine Chemistry'' '''118''', 27-33 (2002). | [4] Ismail, F. "Important Fluorinated Drugs in Experimental and Clinical Use," ''Journal of Fluorine Chemistry'' '''118''', 27-33 (2002). | ||
[5] A Second Look. "Index of Fluorinated Pharmaceuticals," ''Fluoride Toxidity Reserach Collaborative'' (accessed Oct. 19, 2009). http://www.slweb.org/ftrcfluorinatedpharm.html | [5] A Second Look. "Index of Fluorinated Pharmaceuticals," ''Fluoride Toxidity Reserach Collaborative'' (accessed Oct. 19, 2009). http://www.slweb.org/ftrcfluorinatedpharm.html | ||
Latest revision as of 02:41, 20 October 2009
Definition
Fluorination is the chemical process of adding the element fluorine into a molecule. Fluorine has atomic number 9 and is in group 17, the halogens. Fluorination is a kind of halogenation.
Applications
- Fluorinating or applying a fluorinated coating to a surface lowers the surface energy and makes the surface more hydrophobic. Desbief et. al. [3] coat an aluminum surface with fluorinated block copolymers to make the aluminum more hydrophobic.
- Many companies make fluorinated plastic containers that are less permeable than plain HDPE containers.
- Lots of common pharmaceuticals are fluorinated. Fluorinating a pharmaceutical makes it more lipophilic, enhancing absorption of the drug [4]. Common fluorinated pharmaceuticals include Prozac, Paxil, Celebrex, and Lipitor [5]. The pros and cons of fluorinated drugs and their effects on the environment are a topic of debate.
References
[1] "Halogenation," Wikipedia (accessed Oct. 19, 2009). http://en.wikipedia.org/wiki/Halogenation
[2] "Fluorination," The American Heritage Dictionary of the English Langage, Houghton Mifflin Company. 4th Ed. (2000). http://www.thefreedictionary.com/fluorination
[3] Desbief, S., Grignard, B., Detrembleur, C., Rioboo, R., Vaillant, A., Seveno, D., Voue, M., De Coninck, J., Jonas, A.M., Jerome, C., Damman, P., and Lazzaroni, R. "Superhydrophobic Aluminum Surfaces by Deposition of Micelles of Fluorinated Block Copolymers," Langmuir (2009). doi: 10.1021/la902565y.
[4] Ismail, F. "Important Fluorinated Drugs in Experimental and Clinical Use," Journal of Fluorine Chemistry 118, 27-33 (2002).
[5] A Second Look. "Index of Fluorinated Pharmaceuticals," Fluoride Toxidity Reserach Collaborative (accessed Oct. 19, 2009). http://www.slweb.org/ftrcfluorinatedpharm.html
