Difference between revisions of "Fluorination"
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− | * Fluorinating a surface or applying a fluorinated coating lowers the surface energy and makes the surface more hydrophobic. Desbief ''et. al.'' [[Superhydrophobic Aluminum Surfaces by Deposition of Micelles of Fluorinated Block Copolymers|[3] ]] coat an aluminum surface with | + | * Fluorinating a surface or applying a fluorinated coating lowers the surface energy and makes the surface more hydrophobic. Desbief ''et. al.'' [[Superhydrophobic Aluminum Surfaces by Deposition of Micelles of Fluorinated Block Copolymers|[3] ]] coat an aluminum surface with fluorinated block copolymers to make the aluminum more hydrophobic. |
*Many companies make fluorinated plastic containers which are less permeable than simple HDPE containers. | *Many companies make fluorinated plastic containers which are less permeable than simple HDPE containers. |
Revision as of 02:06, 20 October 2009
Definition
Fluorination is the chemical process of adding the element fluorine into a molecule. Fluorine has atomic number 9 and is in group 17, the halogens. Fluorination is a kind of halogenation.
Applications
- Fluorinating a surface or applying a fluorinated coating lowers the surface energy and makes the surface more hydrophobic. Desbief et. al. [3] coat an aluminum surface with fluorinated block copolymers to make the aluminum more hydrophobic.
- Many companies make fluorinated plastic containers which are less permeable than simple HDPE containers.
- Lots of common pharmaceuticals are fluorinated. Fluorinating a pharmaceutical makes it more lipophilic, enhancing absorption of the drug. Some fluorinated pharmaceuticals include Prozac, Paxil, Celebrex, and Lipitor.
References
[1] Halogenation. (accessed Oct. 19, 2009). http://en.wikipedia.org/wiki/Halogenation
[2] Fluorination. "The American Heritage Dictionary of the English Langage," Houghton Mifflin Company. 4th Ed. (2000). http://www.thefreedictionary.com/fluorination
[3] Desbief, S., Grignard, B., Detrembleur, C., Rioboo, R., Vaillant, A., Seveno, D., Voue, M., De Coninck, J., Jonas, A.M., Jerome, C., Damman, P., and Lazzaroni, R. "Superhydrophobic Aluminum Surfaces by Deposition of Micelles of Fluorinated Block Copolymers,"Langmuir (2009). doi: 10.1021/la902565y.
[4] Ismail, F. "Important Fluorinated Drugs in Experimental and Clinical Use," Journal of Fluorine Chemistry 118, 27-33 (2002).
[5] A Second Look. "Index of Fluorinated Pharmaceuticals," Fluoride Toxidity Reserach Collaborative (accessed Oct. 19, 2009). http://www.slweb.org/ftrcfluorinatedpharm.html