Difference between revisions of "Fluorination"

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[4] Ismail, F. Important Fluorinated Drugs in Experimental and Clinical Use. ''Journal of Fluorine Chemistry'' '''118''', 27-33 (2002).
 
[4] Ismail, F. Important Fluorinated Drugs in Experimental and Clinical Use. ''Journal of Fluorine Chemistry'' '''118''', 27-33 (2002).
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[5] http://www.slweb.org/ftrcfluorinatedpharm.html

Revision as of 01:39, 20 October 2009

Definition

Fluorination is the chemical process of adding the element fluorine into a molecule. Fluorine has atomic number 9 and is in group 17, the halogens. Fluorination is a kind of halogenation. This periodic table is from wikimedia commons and shows Fluorine's position at the top of the Halogens (group 17).

Applications

  • Fluorinating a surface or applying a fluorinated coating lowers the surface energy and makes the surface more hydrophobic. Desbief et. al. [3] coat an aluminum surface with a fluorinated block copolymer to make the aluminum more hydrophobic.
  • Many common pharmaceuticals are fluorinated. Fluorinating pharmaceuticals makes them more lipophilic, enhancing absorption of the drug. Some fluorinated pharmaceuticals include Prozac, Paxil, Celebrex, and Lipitor.

References

[1] http://en.wikipedia.org/wiki/Halogenation

[2] http://www.thefreedictionary.com/fluorination

[3] Desbief, S., Grignard, B., Detrembleur, C., Rioboo, R., Vaillant, A., Seveno, D., Voue, M., De Coninck, J., Jonas, A.M., Jerome, C., Damman, P., and Lazzaroni, R. Superhydrophobic Aluminum Surfaces by Deposition of Micelles of Fluorinated Block Copolymers.Langmuir (2009). doi: 10.1021/la902565y.

[4] Ismail, F. Important Fluorinated Drugs in Experimental and Clinical Use. Journal of Fluorine Chemistry 118, 27-33 (2002).

[5] http://www.slweb.org/ftrcfluorinatedpharm.html