Development of functionalized superparamagnetic iron oxide nanoparticles for interaction with human cancer cells

From Soft-Matter
Revision as of 18:30, 23 November 2009 by Kumar (Talk | contribs) (Summary)

Jump to: navigation, search

Original entry by A.J. Kumar, APPHY 225 Fall 2009


A. Petri-Finka, M. Chastellaina, L. Juillerat-Jeanneretb, A. Ferraria, H. Hofmann. Biomaterials 26 (2005) 2685–2694


Melanoma; Human; Iron oxide nanoparticles; Particle size-cell uptake; PVA


The authors set out to develop, characterize, and optimize super-paramagnetic iron oxide nanoparticles (SPIONs) in such a way that they can be internalized by human cancer cells. Such SPIONs can potentially be used both in cancer diagnostics and therapeutics. Examples include: novel MRI technology, drug delivery, and cell separation. The SPIONs alone though will aggregate and will not interact with cells normally so their surface must be coated with polymer and functionalized, both to create a stable colloidal suspension and also to allow the SPIONs to interact with the cells. The authors cite iron oxides as a good material because of low toxicity levels. However recent studies may challenge this (see Iron oxide nanoparticles.

Soft Matter Connection