Comprehensive mapping of long-range interactions reveals folding principles of the human genome

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Entry by Leon Furchtgott, APP 225 Fall 2010.

Erez Lieberman-Aiden*, Nynke L. van Berkum*, et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 326 (2009).

Summary

This paper is about Hi-C, a method that probes the tree-dimensional architecture of whole genomes. The authors construct a spatial proximity map of the human genome with Hi-C at a resolution of 1 megabase. The map shows that the genome is spatially segregated into two genome-wide compartments corresponding to open and closed chromatin. The chromatin conformation is consistent with a fractal globule polymer conformation as opposed to an equilibrium globule conformation.

Background

Results

Fig. 2.

Discussion / Relation to Soft Matter