Difference between revisions of "Comprehensive mapping of long-range interactions reveals folding principles of the human genome"

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(New page: Entry by Leon Furchtgott, APP 225 Fall 2010. Erez Lieberman-Aiden*, Nynke L. van Berkum*, et al. Comprehensive mapping of long-range interactions reveals folding principles of the human g...)
 
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Erez Lieberman-Aiden*, Nynke L. van Berkum*, et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 326 (2009).
 
Erez Lieberman-Aiden*, Nynke L. van Berkum*, et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 326 (2009).
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== Summary ==
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This paper is about Hi-C, a method that probes the tree-dimensional architecture of whole genomes. The authors construct a spatial proximity map of the human genome with Hi-C at a resolution of 1 megabase. The map shows that the genome is spatially segregated into two genome-wide compartments corresponding to open and closed chromatin. The chromatin conformation is consistent with a fractal globule polymer conformation as opposed to an equilibrium globule conformation.
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== Background ==
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== Results ==
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[[Image:bird_prl2.jpg|500px|thumb|center|Fig. 2. ]]
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== Discussion / Relation to Soft Matter ==

Revision as of 13:38, 3 December 2010

Entry by Leon Furchtgott, APP 225 Fall 2010.

Erez Lieberman-Aiden*, Nynke L. van Berkum*, et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 326 (2009).

Summary

This paper is about Hi-C, a method that probes the tree-dimensional architecture of whole genomes. The authors construct a spatial proximity map of the human genome with Hi-C at a resolution of 1 megabase. The map shows that the genome is spatially segregated into two genome-wide compartments corresponding to open and closed chromatin. The chromatin conformation is consistent with a fractal globule polymer conformation as opposed to an equilibrium globule conformation.

Background

Results

Fig. 2.

Discussion / Relation to Soft Matter