Bacteria Pattern Spontaneously on Periodic Nanostructure Arrays

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Entry by Emily Redston, AP 225, Fall 2011

Work in progress


Bacteria Pattern Spontaneously on Periodic Nanostructure Array by A. I. Hochbaum, J. Aizenberg. Nano Lett. 10, 3717-3721 (2010)


Bacterial biofilms naturally form on many surfaces, usually at the solid-liquid or liquid-air interface. Biofilms are composed of many cells embedded within a polymeric organic matrix. While biofilm formation is a concern for many industries, they are especially harmful in the medical community, where they cause extensive damage by triggering the human immune response. Hospital-acquired, or nosocomial, infections affect roughly 10% of patients in the United States, and are responsible for nearly 100,000 deaths. These infections are difficult to treat because the biofilm protects its cells from antibiotic attack. Developing biomedical materials that are resistant to biofilm formation has been a hot topic in research since it would significantly reduce the rate of nosocomial infections and the costs associated with treating them.

In this regard, many people have attempted to use surface chemistry to prevent biofilm formation. Unfortunately, persistently bacteria-resistant materials are difficult to achieve using surface chemistry alone. Even if the bacterial are unable to attach to a substrate directly, nonspecific adsorption of proteins or secreted surfactants to the surface eventually masks the underlying chemical functionality.

In this paper, the authors present a very exciting alternative approach to preventing biofilm formation.

Experimental Set-Up