Written by Yuhang Jin, AP225 2011 Fall.
"Amphiphilic" is used to describe the properties of a certain group of chemicals. A chemical substance being amphiphilic possesses both hydrophilic and lipophilic functional groups. As a result, amphiphilic compounds show good affinity for both water and oil.
Structure and examples of amphiphilic molecules
In amphiphilic molecules, the hydrophilic group is usually charged and highly polar. Examples include carboxylates -CO2- and sulfonates -SO3- with negative charges and amines -NH3+ with positive charges. Sometimes a structure containing a large number of polar, non-charged hydroxyl groups etc. can also serve as the hydrophilic part. The lipophilic part is usually a long chain of nonpolar hydrocarbon structures. The structure of a typical amphiphilic molecule SDS is shown in Figure 1. This special structure leads to relatively high solubility in both polar solvents like water and a large variety of nonpolar solvents.